ValAsta / Astaxanthin and Neuroprotective Activity

ValAsta / Astaxanthin and Neuroprotective Activity

Patented ValAsta / astaxanthin is the only astaxanthin which has been shown to be 500 times more potent than α-tocopherol. ValAsta has the ability to cross the blood–brain-barrier (BBB) and shows antioxidant, and neuroprotective activities. The attached study revealed that astaxanthin (AST) showed neuroprotective activity. Treatment with AST recovered the level of Superoxide Dismutase (SOD) and glutathione while decreased MDA level in the brain tissue. Thus, AST could be an important drug of choice to rescue VPA-induced oxidative stress (Valproic Acid) in autism. Oxidative Stress and Immune System Dysfunction in Autism Spectrum Disorders Natural Antioxidants: A Novel Therapeutic Approach to Autism Spectrum...

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Female Infertility

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067663/Astaxanthin ameliorates inflammation, oxidative stress, and reproductive outcomes in endometriosis patients undergoing assisted reproduction: A randomized, triple-blind placebo-controlled clinical trial - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850816/Ginsenoside Rg1 and astaxanthin act on the hypothalamus to protect female mice against reproductive aging - PMC (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/32512118/Safety assessment of astaxanthin from Haematococcus pluvialis: Acute toxicity, genotoxicity, distribution and repeat-dose toxicity studies in gestation mice - PubMed (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579631/Health Effects of Carotenoids during Pregnancy and Lactation - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098901/Astaxanthin improves the development of the follicles and oocytes through alleviating oxidative stress induced by BPA in cultured follicles - PMC (nih.gov)  https://patents.justia.com/patent/7731992?fbclid=IwAR0LJ9jA32b1nfKD6xkP86pXziC_GQzD_qmduhjrzyfzZaMppU2DAp848FkUS Patent for Method of...

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Dental Health

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983170/Astaxanthin Enhances Gingival Wound Healing following High Glucose-Induced Oxidative Stress - PMC (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/29044575/Investigation of the effect of astaxanthin on alveolar bone loss in experimental periodontitis - PubMed (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019381/Carotenoids and Periodontal Infection - PMC (nih.gov)  https://www.jstage.jst.go.jp/article/jcbn/56/3/56_14-109/_articleAnti-inflammatory effects of astaxanthin in the human gingival keratinocyte line NDUSD-1 (jst.go.jp)

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Blood Cancer

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515619/Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin - PMC (nih.gov)

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Eczema

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811408/Efficacy of Astaxanthin for the Treatment of Atopic Dermatitis in a Murine Model - PMC (nih.gov)  https://www.niaid.nih.gov/diseases-conditions/eczema-atopic-dermatitisEczema (Atopic Dermatitis) | NIH: National Institute of Allergy and Infectious Diseases

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Rosacea

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958186/Rosacea, Reactive Oxygen Species, and Azelaic Acid - PMC (nih.gov)  

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Infectious Diseases

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421583/Astaxanthin protective barrier and its ability to improve the health in patients with COVID-19 - PMC (nih.gov)   https://pubmed.ncbi.nlm.nih.gov/33113418/Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19 - PubMed (nih.gov) 

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Endocrine System

 https://icahealth.com/autoimmunity-inflammation-adrenal-function/ Autoimmunity, Inflammation and Adrenal Function - ICA Health : ICA Health  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876084/Thyroid Hormones and Antioxidant Systems: Focus on Oxidative Stress in Cardiovascular and Pulmonary Diseases - PMC (nih.gov)        

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Pulmonary System

 https://pubmed.ncbi.nlm.nih.gov/33179051/The Promising Effects of Astaxanthin on Lung Diseases - PubMed (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/28963510/A dietary carotenoid reduces immunopathology and enhances longevity through an immune depressive effect in an insect model - PubMed (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/33113418/Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19 - PubMed (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/34557270/Astaxanthin protective barrier and its ability to improve the health in patients with COVID-19 - PubMed (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150233/The Protective Effects of Astaxanthin on the OVA-Induced Asthma Mice Model - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180443/Epidemiologic evidence linking oxidative stress and pulmonary function in healthy populations - PMC (nih.gov)  https://www.nhlbi.nih.gov/health/cystic-fibrosis/treatmentCystic Fibrosis - Treatment | NHLBI, NIH  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876084/Thyroid...

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Animals

 https://pubmed.ncbi.nlm.nih.gov/27293555/Antioxidant supplementation increases retinal responses and decreases refractive error changes in dogs - PubMed (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/20043787/Evaluation of the protective effects of all-trans-astaxanthin on canine osteosarcoma cell lines - PubMed (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898833/Astaxanthin uptake in domestic dogs and cats - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385744/Effects of astaxanthin supplementation in healthy and obese dogs - PMC (nih.gov)  https://reeis.usda.gov/web/crisprojectpages/0182965-dietary-astaxanthin-in-inflammatory-disease-a-rheumatoid-arthritis-model-in-dogs-and-cats.htmlDietary Astaxanthin in Inflammatory Disease: A Rheumatoid Arthritis Model in Dogs and Cats - WASHINGTON STATE UNIVERSITY (usda.gov)  https://ivcjournal.com/support-canine-aging-with-astaxanthin/#:~:text=As%20nature%27s%20most%20powerful%20antioxidant,neutralize%20potentially%20harmful%20free%20radicals.Support canine health and aging with astaxanthin | IVC Journal

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Autism

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247582/Oxidative Stress and Immune System Dysfunction in Autism Spectrum Disorders - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761361/Natural Antioxidants: A Novel Therapeutic Approach to Autism Spectrum Disorders? - PMC (nih.gov)

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Aging Skin

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946307/Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review - PMC (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/28041599/Influence of equol and resveratrol supplementation on health-related quality of life in menopausal women: A randomized, placebo-controlled study - PubMed (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/29163753/Cytoprotective Effects of Citicoline and Homotaurine against Glutamate and High Glucose Neurotoxicity in Primary Cultured Retinal Cells - PubMed (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/23092324/Synergistic effect of L-Carnosine and EGCG in the prevention of physiological brain aging - PubMed (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/23842073/Enhancement of mitochondrial biogenesis with polyphenols: combined effects of resveratrol and equol in human endothelial cells - PubMed (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/20620756/Nutrition and enhancing youthful-appearing skin - PubMed (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/18784933/A new view...

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Ovarian Cancer

 https://www.researchgate.net/publication/309401004Could we use antioxidants during cancer chemotherapy or not? | Request PDF (researchgate.net)   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266165/Astaxanthin Prevents Human Papillomavirus L1 Protein Binding in Human Sperm Membranes - PMC (nih.gov)    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911626/Antioxidants and Therapeutic Targets in Ovarian Clear Cell Carcinoma - PMC (nih.gov)

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Cancer

 https://pubmed.ncbi.nlm.nih.gov/10798217/Antitumor activity of astaxanthin and its mode of action - PubMed (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/10470126/A comparison of the anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo - PubMed (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210693/Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro - PMC (nih.gov)  https://www.sciencedirect.com/science/article/abs/pii/S0024320502015229Contribution of the antioxidative property of astaxanthin to its protective effect on the promotion of cancer metastasis in mice treated with restraint stress - ScienceDirect  https://www.mdpi.com/2072-6694/12/9/2425Cancers | Free Full-Text | Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back (mdpi.com)  https://www.sciencedirect.com/science/article/abs/pii/S1043661819327367Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A...

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Metabolic Syndrome

 https://pubmed.ncbi.nlm.nih.gov/29384321/Astaxanthin improves glucose metabolism and reduces blood pressure in patients with type 2 diabetes mellitus - PubMed (nih.gov)   https://pubmed.ncbi.nlm.nih.gov/15096660/Prevention of diabetic nephropathy by treatment with astaxanthin in diabetic db/db mice - PubMed (nih.gov)  https://www.mdpi.com/1660-3397/18/7/357Marine Drugs | Free Full-Text | Impact of Astaxanthin on Diabetes Pathogenesis and Chronic Complications (mdpi.com)  https://pubmed.ncbi.nlm.nih.gov/30217037/Astaxanthin Prevents Alcoholic Fatty Liver Disease by Modulating Mouse Gut Microbiota - PubMed (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/33207669/Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions - PubMed (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/25761053/Protective effects of astaxanthin on ConA-induced autoimmune hepatitis by the JNK/p-JNK pathway-mediated inhibition of autophagy and apoptosis - PubMed...

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Fitness

 https://pubmed.ncbi.nlm.nih.gov/24688216/The astaxanthin-induced improvement in lipid metabolism during exercise is mediated by a PGC-1α increase in skeletal muscle - PubMed (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/26603489/Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E - PubMed (nih.gov)  https://www.peacehealth.org/medical-topics/id/hn-10011675Astaxanthin for Sports & Fitness – Health Information Library | PeaceHealth  https://www.sciencedirect.com/science/article/abs/pii/S0765159719300322Effect of astaxanthin and exercise on antioxidant capacity of human body, blood lactic acid and blood uric acid metabolism - ScienceDirect  https://pubmed.ncbi.nlm.nih.gov/12626126/Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice - PubMed (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/21984399/Effect of astaxanthin on cycling time trial performance - PubMed (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/29495607/Effects of Dietary Supplementation of...

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Bone and Joint

 https://pubmed.ncbi.nlm.nih.gov/29562730/Suppression Effect of Astaxanthin on Osteoclast Formation In Vitro and Bone Loss In Vivo - PubMed (nih.gov)  https://pubs.rsc.org/en/content/articlelanding/2022/FO/D2FO01673GAstaxanthin attenuates irradiation-induced osteoporosis in mice by inhibiting oxidative stress, osteocyte senescence, and SASP - Food & Function (RSC Publishing)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900941/Antioxidant Intake and Risks of Rheumatoid Arthritis and Systemic Lupus Erythematosus in Women - PMC (nih.gov)

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Cardiovascular System

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696511/Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723678/Antioxidant and anti-inflammatory mechanisms of action of astaxanthin in cardiovascular diseases (Review) - PMC (nih.gov)  https://www.healthline.com/health/is-the-heart-a-muscleIs the Heart a Muscle? Anatomy, Heart Conditions, and More (healthline.com)  https://www.healthline.com/health/arteries-of-the-bodyArteries of the Body: Picture, Anatomy, Definition & More (healthline.com)  https://www.healthline.com/health/venous-systemVenous System: Vein Anatomy and Function, Vein Types, Conditions (healthline.com)  https://www.mdpi.com/2076-3921/9/9/864Antioxidants | Free Full-Text | Oxidative Stress in Cardiovascular Diseases (mdpi.com)  https://pubmed.ncbi.nlm.nih.gov/21964877/Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects - PubMed (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/26861359/Potential Anti-Atherosclerotic Properties of Astaxanthin - PubMed (nih.gov)   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148495/Marine...

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Reactive Oxygen Species (ROS)

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614697/Free Radicals, Antioxidants in Disease and Health - PMC (nih.gov)  https://pubs.niaaa.nih.gov/publications/arh27-4/277-284.pdfAlcohol, Oxidative Stress, and Free Radical Damage (nih.gov)  https://www.hindawi.com/journals/mi/2010/453892/#B112Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis (hindawi.com)  https://algalif.is/wp-content/uploads/2020/08/Algalif_Natural-Astaxanthin_Review-of-Human-Clinical-Studies-_0917_web.pdfAlgalif_Natural-Astaxanthin_Review-of-Human-Clinical-Studies-_0917_web.pdf  https://health.clevelandclinic.org/free-radicals/Free Radicals: How They Affect Your Body – Cleveland Clinic  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946307/Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review - PMC (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/33108581/Astaxanthin protects oxidative stress mediated DNA damage and enhances longevity in Saccharomyces cerevisiae - PubMed (nih.gov)  https://www.hindawi.com/journals/ijfs/2020/2156582/Structures of Astaxanthin and Their Consequences for Therapeutic Application (hindawi.com)  https://www.webmd.com/arthritis/ss/slideshow-signs-chronic-inflammation-unexpected?ecd=wnl_spr_051022_remail&ctr=wnl-spr-051022-remail_lead_title&mb=hJ2mACnP7XzjHpF%40zUlTLipiMzVEF17PRAQe0sSHwaU%3D Pictures: Signs of Chronic Inflammation You May Not Expect (webmd.com)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876084/Thyroid Hormones and Antioxidant Systems: Focus on...

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Eye Diseases

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705160/Effects of astaxanthin on antioxidation in human aqueous humor - PMC (nih.gov)  https://www.mayoclinic.org/diseases-conditions/blepharitis/symptoms-causes/syc-20370141Blepharitis - Symptoms and causes - Mayo Clinic  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281326/Clinical Applications of Astaxanthin in the Treatment of Ocular Diseases: Emerging Insights - PMC (nih.gov)   https://www.naturalproductsinsider.com/healthy-aging/astaxanthin-healthy-agingHealthy aging and astaxantin (naturalproductsinsider.com)

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Integumentary (Skin) System

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811408/Efficacy of Astaxanthin for the Treatment of Atopic Dermatitis in a Murine Model - PMC (nih.gov)  https://www.niaid.nih.gov/diseases-conditions/eczema-atopic-dermatitisEczema (Atopic Dermatitis) | NIH: National Institute of Allergy and Infectious Diseases  https://pubmed.ncbi.nlm.nih.gov/28751807/Protective effects of astaxanthin on skin deterioration - PubMed (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516620/Effect of astaxanthin on cutaneous wound healing - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946307/Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review - PMC (nih.gov)  https://www.naturalproductsinsider.com/healthy-aging/astaxanthin-healthy-agingHealthy aging and astaxantin (naturalproductsinsider.com)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073124/The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People—A Randomized, Double-Blind, Placebo-Controlled Trial - PMC (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/28041599/Influence of equol and resveratrol supplementation on health-related quality of life in menopausal women: A...

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Autoimmune Disorders

 https://www.naturalproductsinsider.com/healthy-aging/astaxanthin-healthy-agingHealthy aging and astaxantin (naturalproductsinsider.com)  https://pubmed.ncbi.nlm.nih.gov/20205737/Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans - PubMed (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/29536745/Astaxanthin effectiveness in preventing multiple sclerosis in animal model - PubMed (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914430/Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis - PMC (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/33207669/Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions - PubMed (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/31772142/ Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis - PubMed (nih.gov)  https://www.spandidos-publications.com/10.3892/mmr.2020.11284A potential role for astaxanthin in the treatment of bone diseases (Review) (spandidos-publications.com)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900941/Antioxidant Intake and Risks of Rheumatoid Arthritis and Systemic...

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Male Infertility

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721213/Effect of Astaxanthin on Human Sperm Capacitation - PMC (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/34940651/Inhibitory Effect of Astaxanthin on Testosterone-Induced Benign Prostatic Hyperplasia in Rats - PubMed (nih.gov)  https://rbej.biomedcentral.com/articles/10.1186/s12958-018-0406-2Reactive oxygen species and male reproductive hormones | Reproductive Biology and Endocrinology | Full Text (biomedcentral.com)

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Breast Cancer

 https://www.lifeextension.com/magazine/2017/12/update-astaxanthinNew Research on Astaxanthin and Cancer - - Life Extension  https://pubmed.ncbi.nlm.nih.gov/26693355/C-Reactive Protein and Breast Cancer: New Insights from Old Molecule - PubMed (nih.gov)  https://www.researchgate.net/publication/309401004Could we use antioxidants during cancer chemotherapy or not? | Request PDF (researchgate.net)   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515619/Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin - PMC (nih.gov)   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210693/Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752924/Structural and Functional Characterization of Aromatase, Estrogen Receptor, and Their Genes in Endocrine-Responsive and – Resistant Breast Cancer Cells - PMC (nih.gov)   https://patents.justia.com/patent/7731992?fbclid=IwAR0LJ9jA32b1nfKD6xkP86pXziC_GQzD_qmduhjrzyfzZaMppU2DAp848FkUS Patent for Method of inhibiting aromatase with specific dietary supplements Patent (Patent #...

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Prostate Cancer

 https://pubmed.ncbi.nlm.nih.gov/28282880/Astaxanthin Inhibits PC-3 Xenograft Prostate Tumor Growth in Nude Mice - PubMed (nih.gov)  https://www.lifeextension.com/magazine/2017/12/update-astaxanthinNew Research on Astaxanthin and Cancer - - Life Extension   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266165/Astaxanthin Prevents Human Papillomavirus L1 Protein Binding in Human Sperm Membranes - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459748/Anti-Tumor Effects of Astaxanthin by Inhibition of the Expression of STAT3 in Prostate Cancer - PMC (nih.gov)

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Colorectal Cancer

 https://www.sciencedirect.com/science/article/abs/pii/S1043661819327367Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A systematic review - ScienceDirect  https://www.lifeextension.com/magazine/2017/12/update-astaxanthinNew Research on Astaxanthin and Cancer - - Life Extension   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515619/Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin - PMC (nih.gov)   https://www.researchgate.net/publication/309401004Could we use antioxidants during cancer chemotherapy or not? | Request PDF (researchgate.net)   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515619/Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266165/Astaxanthin Prevents Human Papillomavirus L1 Protein Binding in Human Sperm Membranes - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603017/Astaxanthin suppresses the metastasis of colon cancer by inhibiting the MYC-mediated downregulation of microRNA-29a-3p and microRNA-200a - PMC (nih.gov)

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Lung Cancer

 https://www.lifeextension.com/magazine/2017/12/update-astaxanthinNew Research on Astaxanthin and Cancer - - Life Extension  https://www.researchgate.net/publication/309401004Could we use antioxidants during cancer chemotherapy or not? | Request PDF (researchgate.net)   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515619/Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin - PMC (nih.gov)   https://pubmed.ncbi.nlm.nih.gov/33179051/The Promising Effects of Astaxanthin on Lung Diseases - PubMed (nih.gov) 

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Oral Cancer

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189964/Astaxanthin Inhibits JAK/STAT-3 Signaling to Abrogate Cell Proliferation, Invasion and Angiogenesis in a Hamster Model of Oral Cancer - PMC (nih.gov)  https://www.lifeextension.com/magazine/2017/12/update-astaxanthinNew Research on Astaxanthin and Cancer - - Life Extension   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515619/Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin - PMC (nih.gov)

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Pancreatic | Liver | Gallbladder Cancer

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652142/Astaxanthin inhibits gemcitabine-resistant human pancreatic cancer progression through EMT inhibition and gemcitabine resensitization - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659906/pdf/tjg-31-10-706.pdfAstaxanthin alleviates oxidative damage in acute pancreatitis via direct antioxidant mechanisms  https://aacrjournals.org/mcr/article/10/1/52/89126/STEAP1-Is-Associated-with-the-Invasive-and?searchresult=1STEAP1 Is Associated with the Invasive and Oxidative Stress Phenotype of Ewing Tumors | Molecular Cancer Research | American Association for Cancer Research (aacrjournals.org)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293384/Astaxanthin in Liver Health and Disease: A Potential Therapeutic Agent - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875360/Iron Overload Damages the Endothelial Mitochondria via the ROS/ADMA/DDAHII/eNOS/NO Pathway - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164583/Astaxanthin Prevents Alcoholic Fatty Liver Disease by Modulating Mouse Gut Microbiota - PMC (nih.gov)  http://science.naturalnews.com/pubmed/20038455.htmlScience.NaturalNews.com - Conduct powerful scientific research in mere seconds...

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Skin Cancer

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946307/Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review - PMC (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/29136080/Ultraviolet radiation-induced immunosuppression and its relevance for skin carcinogenesis - PubMed (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/11101875/Immune suppression and skin cancer development: regulation by NKT cells - PubMed (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279601/The Immunologic Revolution: Photoimmunology - PMC (nih.gov)  https://www.sciencedirect.com/science/article/abs/pii/S1043661819327367Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A systematic review - ScienceDirect  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515619/Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin - PMC (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/31370257/Do We Utilize Our Knowledge of the Skin Protective Effects of Carotenoids Enough? - PubMed (nih.gov)   https://pubmed.ncbi.nlm.nih.gov/29246280/Continuous astaxanthin intake reduces oxidative stress and reverses age-related morphological changes of residual skin...

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Gastric Cancer

 https://www.sciencedirect.com/science/article/pii/S1043661819327367Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A systematic review - ScienceDirect  https://www.lifeextension.com/magazine/2017/12/update-astaxanthinNew Research on Astaxanthin and Cancer - - Life Extension  https://www.researchgate.net/publication/309401004Could we use antioxidants during cancer chemotherapy or not? | Request PDF (researchgate.net)  https://www.mdpi.com/2072-6643/10/9/1320Nutrients | Free Full-Text | Astaxanthin Inhibits Mitochondrial Dysfunction and Interleukin-8 Expression in Helicobacter pylori-Infected Gastric Epithelial Cells (mdpi.com)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849689/Astaxanthin Inhibits Proliferation of Human Gastric Cancer Cell Lines by Interrupting Cell Cycle Progression - PMC (nih.gov)  https://www.mdpi.com/2072-6643/13/12/4281Nutrients | Free Full-Text | Inhibitory Effect of Astaxanthin on Gene Expression Changes in Helicobacter pylori-Infected Human Gastric Epithelial Cells (mdpi.com)

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Brain Cancer

 https://www.timesgazette.com/2020/03/04/is-it-a-cure-for-cancer-and-more/Is it a cure for cancer and more? - The Times Gazette   https://pubmed.ncbi.nlm.nih.gov/32962073/Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma - PubMed (nih.gov)

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Bladder Cancer

 https://files.constantcontact.com/9eda6866701/11710007-422e-4730-8a94-6f57c3cc5c34.pdfOxidative Stress and Bladder Cancer Carcinogenesis: Early Detection and Chemoprevention Involving Nrf2—an Integrative Approach (constantcontact.com)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515619/Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin - PMC (nih.gov)   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266165/Astaxanthin Prevents Human Papillomavirus L1 Protein Binding in Human Sperm Membranes - PMC (nih.gov)

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Bone Cancer

 https://files.constantcontact.com/9eda6866701/d8e00c92-2ca0-45a3-8317-6cebe4572c8e.pdfd8e00c92-2ca0-45a3-8317-6cebe4572c8e.pdf (constantcontact.com)  https://aacrjournals.org/mcr/article/10/1/52/89126/STEAP1-Is-Associated-with-the-Invasive-and?searchresult=1STEAP1 Is Associated with the Invasive and Oxidative Stress Phenotype of Ewing Tumors | Molecular Cancer Research | American Association for Cancer Research (aacrjournals.org)

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Lyme Disease

 https://www.lymedisease.org/rawls-natural-remedies-lyme/Natural remedies for the chronic inflammation of Lyme disease

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Osteoporosis

 https://pubs.rsc.org/en/content/articlelanding/2022/FO/D2FO01673GAstaxanthin attenuates irradiation-induced osteoporosis in mice by inhibiting oxidative stress, osteocyte senescence, and SASP - Food & Function (RSC Publishing)

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Macular Degeneration

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281326/Clinical Applications of Astaxanthin in the Treatment of Ocular Diseases: Emerging Insights - PMC (nih.gov)  https://www.naturalproductsinsider.com/healthy-aging/astaxanthin-healthy-agingHealthy aging and astaxantin (naturalproductsinsider.com)

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Gastrointestinal Disorders

 https://pubmed.ncbi.nlm.nih.gov/28698858/Astaxanthin and β-carotene in Helicobacter pylori-induced Gastric Inflammation: A Mini-review on Action Mechanisms - PubMed (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404279/Transcriptome Analysis of the Inhibitory Effect of Astaxanthin on Helicobacter pylori-Induced Gastric Carcinoma Cell Motility - PMC (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/21621527/Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines - PubMed (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917265/Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348411/Astaxanthin, a xanthophyll carotenoid, prevents development of dextran sulphate sodium-induced murine colitis - PMC (nih.gov)  https://www.sciencedirect.com/science/article/abs/pii/S0009279711002171Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines - ScienceDirect...

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Extreme Athletes

 https://www.mdpi.com/2073-4409/11/5/899/htmCells | Free Full-Text | Redox Implications of Extreme Task Performance: The Case in Driver Athletes (mdpi.com)  https://www.ncbi.nlm.nih.gov/books/NBK299041/Inflammation and Immune Function - Antioxidants in Sport Nutrition - NCBI Bookshelf (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947967The astaxanthin-induced improvement in lipid metabolism during exercise is mediated by a PGC-1α increase in skeletal muscle - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333958/Oxidative stress status in elite athletes engaged in different sport disciplines - PMC (nih.gov)  https://www.peacehealth.org/medical-topics/id/hn-10011675Astaxanthin for Sports & Fitness – Health Information Library | PeaceHealth  https://www.sciencedirect.com/science/article/abs/pii/S0765159719300322Effect of astaxanthin and exercise on antioxidant capacity of human body, blood lactic acid and blood uric acid metabolism - ScienceDirect  https://pubmed.ncbi.nlm.nih.gov/12626126/Astaxanthin limits exercise-induced skeletal...

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Reproductive System

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067663/Astaxanthin ameliorates inflammation, oxidative stress, and reproductive outcomes in endometriosis patients undergoing assisted reproduction: A randomized, triple-blind placebo-controlled clinical trial - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850816/Ginsenoside Rg1 and astaxanthin act on the hypothalamus to protect female mice against reproductive aging - PMC (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/32512118/Safety assessment of astaxanthin from Haematococcus pluvialis: Acute toxicity, genotoxicity, distribution and repeat-dose toxicity studies in gestation mice - PubMed (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721213/Effect of Astaxanthin on Human Sperm Capacitation - PMC (nih.gov)  https://pubmed.ncbi.nlm.nih.gov/34940651/Inhibitory Effect of Astaxanthin on Testosterone-Induced Benign Prostatic Hyperplasia in Rats - PubMed (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579631/Health Effects of Carotenoids during Pregnancy and Lactation - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098901/Astaxanthin improves the...

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Neurological Diseases

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070237/The Use of Antioxidants in the Treatment of Migraine - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591755/Marine algae as emerging therapeutic alternatives for depression: A review - PMC (nih.gov)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110951/The Impact of Systemic Inflammation on Neurodevelopment - PMC (nih.gov)  https://hms.harvard.edu/magazine/aging/inflammation-brain-healthInflammation and Brain Health | Harvard Medicine magazine  https://lktlabs.com/astaxanthin-antitumor-effect/Astaxanthin Antitumor Effect - LKT Labs  https://pubmed.ncbi.nlm.nih.gov/22962526/ Effects of astaxanthin-rich Haematococcus pluvialis extract on cognitive function: a randomised, double-blind, placebo-controlled study - PubMed (nih.gov)  https://ffhdj.com/index.php/ffhd/article/view/636/1058Effect of Astaxanthin Supplementation on Psychophysiological Heart-Brain Axis Dynamics in Healthy Subjects | Talbott | Functional Foods in Health and Disease (ffhdj.com)  https://pubmed.ncbi.nlm.nih.gov/32384730/Oxidative Stress and Immune System Dysfunction in Autism Spectrum Disorders - PubMed...

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